New Yorker : "In the late eighties, doctors had prescribed Nardil for Wallace’s depression. Nardil, an antidepressant developed in the late fifties, is a monoamine oxidase inhibitor that is rarely given for long periods of time, because of its side effects, which include low blood pressure and bloating. Nardil can also interact badly with many foods. One day in the spring of 2007, when Wallace was feeling stymied by the Long Thing, he ate at a Persian restaurant in Claremont, and afterward he went home ill. A doctor thought that Nardil might be responsible. For some time, Wallace had come to suspect that the drug was also interfering with his creative evolution. He worried that it muted his emotions, blocking the leap he was trying to make as a writer. He thought that removing the scrim of Nardil might help him see a way out of his creative impasse. Of course, as he recognized even then, maybe the drug wasn’t the problem; maybe he simply was distant, or maybe boredom was too hard a subject. He wondered if the novel was the right medium for what he was trying to say, and worried that he had lost the passion necessary to complete it. That summer, Wallace went off the antidepressant. He hoped to be as drug free as Don Gately, and as calm. Wallace would finish the Long Thing with a clean brain. He entered this new period of life with what Franzen calls “a sense of optimism and a sense of terrible fear.” He hoped to be a different person and a different writer. “That’s what created the tension,” Franzen recalls. “And he didn’t make it.”"